New viral vectors for infectious diseases and cancer

Novel viral vectors in infectious diseases

Since the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous viruses in vaccination strategies has been explored. In recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacy. Furthermore, exciting new vectors that exploit viruses such as cytomegalovirus (CMV) and vesic...

Application of bacterial shuttle vectors in designing new vaccines against infectious diseases: brief report

Background: Today, several vaccines have been developed to prevent infectious diseases. The older first-generation vaccines may have many problems. In this regard, genetic engineering plays an important role using tools such as shuttle vectors to develop recombinant DNA vaccines that usually include plasmid constructed so that can propagate in two different host species. The present study revie...

Cancer research meets tick vectors for infectious diseases.

Arenaviral vaccine vectors to combat infectious diseases

In recent years, the use of viral vaccine vectors has gained immense interest over traditional vaccine strategies due to their ability to replicate in order to induce high immune responses against the intended antigens without the need for adjuvant co-administration. Several viral vectors, including but not necessarily limited to adenoviruses, poxviruses and alphaviruses are currently in variou...

AAV Vectors Vaccines Against Infectious Diseases

Since their discovery as a tool for gene transfer, vectors derived from the adeno-associated virus (AAV) have been used for gene therapy applications and attracted scientist to this field for their exceptional properties of efficiency of in vivo gene transfer and the level and duration of transgene expression. For many years, AAVs have been considered as low immunogenic vectors due to their abi...